目的 评价不同补充和替代医学(complementary and alternative medicine,CAM)疗法对缓解新生儿足跟采血疼痛的应用效果。 方法 计算机检索PubMed、Embase、Web of Science、Cochrane、CINAHL、中国知网、维普、万方、中国生物医学文献数据库，时限为建库至2022年2月。采用Cochrane 5.1.0手册进行质量评价，Stata 15.0进行频率学网状Meta分析。 结果 共纳入44篇随机对照试验（足月儿29篇、早产儿15篇），涉及15种CAM（足月儿14种、早产儿7种），5206例新生儿（足月儿4337例、早产儿869例）。研究显示：对足月儿，12种CAM缓解疼痛的效果均优于常规干预(均P＜0.05)，母乳吮吸的汇总累积排序概率图下面积（surface under the cumulative,SUCRA）最大；对早产儿，5种CAM缓解疼痛的效果均优于常规干预(均P＜0.05)，音乐+非营养性吮吸（non-nutritive sucking,NNS）的SUCRA最大。 结论 母乳吮吸缓解足月儿疼痛效果最佳，音乐+NNS缓解早产儿疼痛效果最佳；此外，音乐联合干预效果比音乐单独干预更佳；研究结果对临床护理人员干预新生儿疼痛具有指导意义。

Objective To evaluate the effect of various complementary and alternative medicines (CAM) on relieving the pain of newborns caused by heel blood collection. Methods The databases of PubMed,Embase,Web of Science,Cochrane,CINAHL,CNKI,VIP,Wanfang,and CBM were searched from the inception up to February 2022.The Cochrane 5.1.0 Handbook was used to assess the quality of the included studies.Stata15.0 software was used for frequency reticulation meta-analysis. Results A total of 44 randomized controlled trials (29 for term-infants and 15 for preterm-infants) were included,involving 15 CAM(14 term-infants and 7 premature-infants),with a total of 5206 patients (4337 term infants and 869 preterm infants).For full-term infants,12 CAM on pain relief were better than conventional intervention (all P＜0.05),and surface under the cumulative (SUCRA) of breast-feeding was the largest.For premature infants,5 CAM were superior to conventional interventions (all P＜0.05),and SUCRA of music and non-nutritive sucking (NNS) was the largest. Conclusions Breast-feeding is the best way to relieve pain in full-term infants,and music and NNS are the best way to relieve pain in premature infants.Moreover,the combined music intervention is more effective than the music alone.It has guiding significance for nursing staff to intervene in neonatal pain.

R473.72

成都中医药大学“杏林学者”学科人才科研提升计划（编号：MPRC2021021）、2022年四川省心理健康教育研究中心项目（编号：XLJKJY2203A）