目的 了解多阶段优化策略（multiphase optimization strategy,MOST）在慢性病多因素干预中的应用阶段及效果，以期为国内慢性病多因素干预模式构建及MOST持续完善提供思路。方法 按照范围综述的研究范式，系统检索8个中英文数据库中相关文献，检索时限自建库到2023年12月22日。结果 共纳入16篇文献，包括:癌症10篇，糖尿病2篇，高血压、急性冠状动脉综合征、心肺衰竭、哮喘各1篇；主要应用于心理问题、症状管理等需多个因素共同管理的复杂护理方案及健康教育宣传单的优化；主要优势为针对单一干预要素进行效果评价，劣势为缺乏客观性及科学标准的报告清单。结论 MOST在慢性病多因素干预中的应用尚处于起步阶段，各阶段研究方案有待进一步落实。未来应完善MOST并充分发挥其优势，促进慢性病多因素管理方案的切实可及。

Objective To understand the application stages and effects of the Multiphase Optimization Strategy (MOST) in multifactorial intervention for chronic diseases,so as to provide suggestions for the building of a multifactorial intervention model for chronic diseases in China,as well as the continual improvement of MOST.Methods According to the methodology framework of scoping review,relevant literatures in 8 Chinese and English databases were systematically searched from the databases’ inception to December 22,2023.Results A total of 16 literatures were included,including 10 studies on cancer,2 studies on diabetes,1 study on hypertension,1 study on post acute coronary syndrome (Post-ACS),1 study on cardiopulmonary failure and 1 study on asthma.It is mostly used to optimize complex nursing programs and health education leaflets that required co-management of multiple factors such as psychological issues and symptom management.The main advantage of MOST is that it can evaluate the effect of a single intervention component,and the disadvantage is that it lacks objectivity and scientific standards.Conclusions The application of MOST in multifactorial intervention of chronic diseases is still in its infancy,and the research programs in each stage need to be further implemented.Future developments in the MOST should be pursued in order to fully realize its benefits and encourage the availability of multifactorial management plans for chronic illnesses.

R47-05

甘肃省科技计划项目（20JR10RA637）；中央高校基本科研业务费项目（lzujbky-2022-30）；兰州大学护理学院教学改革项目（LZUHL-JXXM-202206）