目的 总结评估与预防儿童经皮肝脏活检术出血的最佳循证医学证据，为临床工作者提供指导。方法 系统检索各中英文数据库以及指南网站中有关经皮肝脏活检术出血评估与预防的临床决策、指南、最佳实践、证据总结、专家共识、系统评价。检索时限为各数据库建库至2022年8月16日。采用相应工具对文章进行质量评价，采用澳大利亚Joanna Briggs循证卫生保健中心证据分级及推荐级别系统对证据进行汇总、评价和等级划分。结果 最终纳入10篇文献，其中3篇临床决策、2篇指南、1篇证据总结、3篇专家共识、1篇系统评价，归纳总结了22条关于儿童经皮肝脏活检术出血评估与预防的最佳证据。结论 儿童经皮肝脏活检术出血的管理，早期识别及预防是关键；建议将超声贯穿于围术期全过程，以期确保操作安全实施及早期识别有出血并发症的患儿。

Objective To summarize the best evidence-based medical evidence to evaluate and prevent bleeding during percutaneous liver biopsy in children,so as to provide guidance for clinicians.Methods Clinical decision-making,clinical practice guidelines,best practices recommendations,evidence summaries,expert consensus,and systematic reviews related to bleeding after percutaneous liver biopsy bleeding assessment and prevention were systematically searched from Chinese and English databases and guideline websites.The search period extended from the inception of each database up until August 16,2022.Relevant tools were used to evaluate the quality of the articles,and the evidence was summarized,evaluated and graded using the evidence grading and recommendation grading system of Joanna Briggs Institute Evidence-Based Health Care Center in Australia.Results A total of 10 literatures were incorporated,including 3 clinical decision-making,2 guidelines,1 evidence summary,3 expert consensus,and 1 systematic review,and 22 best evidences on the evaluation and prevention of bleeding in children with percutaneous liver biopsy were summarized.Conclusions The management,early recognition and prevention of bleeding during percutaneous liver biopsy in children are of vital importance.It is recommended to carry out ultrasound throughout the perioperative period to ensure safe execution of procedures and the early detection of bleeding complications in children.

R472.9