目的 评价微环境pH值调适对糖尿病足溃疡的治疗效果。方法 选取上海市某三级甲等医院糖尿病足多学科联合门诊就诊患者随机分为两组，对照组接受糖尿病足溃疡常规专科护理，干预组根据创面pH值应用酸性液进行微环境pH值调适。比较两组患者干预前后创面pH值、压疮愈合量表评分及愈合率等。结果 干预前两组创面pH值处于碱性范围，干预后第2、4、8周干预组创面pH值和创面面积小于对照组，干预组达到50 %愈合所需时间短于对照组，观察期结束时干预组创面愈合率高于对照组，差异均有统计学意义（均P＜0.05）。结论 对糖尿病足溃疡进行微环境pH值调适可缩短创面愈合时间，改善感染程度，提高创面愈合率，对促进糖尿病足溃疡的修复具有重要作用。

Objective To evaluate the effect of pH value modulation on the treatment of diabetic foot ulcers.Methods Patients who visited the Diabetes Foot Multidisciplinary Joint Clinic of a tertiary A hospital in Shanghai were randomly divided into the intervention group and the control group.The control group received routine nursing care for diabetic foot ulcer and the intervention group received acidic liquid dressing to adjust the pH value of the wound according to the pH value of the wound.The pH value of the wound,PUSH score and wound healing rate were compared between the two groups before and after the intervention.Results Before intervention,the pH value of the two groups of wounds was in the alkaline range.The pH value and wound area of the intervention group were smaller than those of the control group in the 2nd,4th and 8th week after the intervention.The time required to achieve 50% healing of the intervention group was shorter than that of the control group.At the end of the observation period,the wound healing rate of the intervention group was higher than that of the control group and the differences were statistically significant (all P＜0.05).Conclusions The modulation of the pH value of diabetic foot ulcers can shorten the time of wound healing,reduce infection grading,and improve the wound healing rate,which plays an important role in promoting the healing of diabetic foot ulcers.

R473.58

复旦大学-复星护理科研基金(FNF202224)