目的 探讨多感官刺激联合多领域认知训练对阿尔茨海默病患者（Alzheimer’s disease,AD）精神行为症状的影响。方法 便利抽样选取2023年2-4月某医院神经内科病房收治的AD患者共94例，对照组予常规护理，试验组在此基础上实施多感官刺激联合多领域认知训练。干预前后采用神经精神量表（neu-ropsychiatric inventory，NPI）、科恩-曼斯菲尔德激越行为量表（Cohen-Mansfield agitation inventory ,CMAI）、汉密尔顿焦虑量表 (Hamilton anxiety scale,HAMA)和汉密尔顿抑郁量表（Hamilton depression scale,HAMD）评价两组患者的精神行为、情绪变化。结果 试验组患者在接受干预后的NPI、CMAI、HAMA和HAMD评分明显低于对照组（均P＜0.05）。结论 对AD患者实施多感官刺激联合多领域认知训练，可有效降低其激越行为的发生率，改善焦虑和抑郁等负面情绪。

Objective To explore the effect of multi-sensory stimulation combined with multi-domain cognitive training on behavioral and psychological symptoms of dementia patients with Alzheimer’s disease(AD). Methods 94 AD patients were selected from the neurology ward of a hospital from February to April,2023. They were randomly divided into the experimental group(47 patients) and the control group(47 patients). The control group was given routine nursing care,and the experimental group was given multi-sensory stimulation combined with multi-field cognitive training. Neu-ropsychiatric inventory (NPI),Cohen-Mansfield Agitation Inventory (CMAI) and Hamilton anxiety scale(HAMA) and Hamilton Depression Scale(HAMD) were used to evaluate and compare the mental behaviors and emotional changes of the two groups before and after the intervention.Results The scores of NPI,CMAI,HAMA and HAMD in the experimental group were significantly lower than those in the control group(P＜0.05).Conclusions Multi-sensory stimulation combined with multi-field cognitive training can effectively reduce the incidence of agitated behaviors in AD patients and relieve their negative emotion such as anxiety and depression.

R47

首都医科大学2023年教育教学改革研究立项课题（2023JYY118）