目的 系统评价缺血性脑卒中后认知障碍风险预测模型性能，为预测缺血性脑卒中后患者的认知功能和相关模型的构建及应用提供参考。方法 计算机检索知网、万方、维普、PubMed、EMbase、The Cochrane Library等数据库中缺血性脑卒中后认知障碍风险预测模型相关的研究，检索时限均从建库至2023年5月。由2位评价员筛选文献、提取资料并评价纳入研究的偏倚风险和适用性。 结果 共纳入16个缺血性脑卒中后患者的认知障碍风险预测模型；预测模型整体偏倚风险较高；其中5个模型适用性较好，11个模型适用性较差，受试者工作特征曲线下面积为0.708~0.913。常见的预测因子为年龄、受教育水平、NIHSS评分、梗死分区等。纳入模型主要的高风险偏倚在研究对象和统计分析方面。结论 现有的缺血性脑卒中后认知障碍风险预测模型的整体预测性能较差，模型的临床适用价值需要进一步验证。

Objective To systematically evaluate the risk prediction model of cognitive impairment after ischemic stroke,so as to provide reference for the prediction of cognitive function in such patients and the construction and application of related models.Methods A computerized search of CNKI,Wanfang,VIP,CBM,PubMed,EMbase,the Cochrane Library,and Web of Science was conducted to collect studies on the risk prediction model of cognitive impairment after ischemic stroke,with the timeframe from the inception to May 2023.Two evaluators screened the literature,extracted information,and evaluated the risk of bias and applicability of the included studies.Results A total of 16 studies on predictive modeling of cognitive impairment in patients after ischemic stroke were included.The overall risk of bias of the included models was high,the applicability of 5 studies good,the applicability of 11 studies poor,and the area under the working characteristic curve of the subjects ranged from 0.708 to 0.913.The common predictors were age,level of education,NIHSS scores,and infarct zonation,etc.The main high risk of bias for inclusion in the model was in the domain of the study subjects and statistical analysis.Conclusions The overall performance of the existing models for predicting the risks of cognitive impairment after ischemic stroke is poor,and the clinical applicability value of the models needs to be further validated.

R473.74

河南省医学科技攻关计划省部共建项目(SBGJ 202102001)