目的 探讨未破裂颅内动脉瘤（unruptured intracranial aneurysm，UIA）患者焦虑和抑郁的发生率，为临床制订心理干预方案提供参考。方法 计算机检索中英文数据库中关于UIA患者焦虑、抑郁发生率的观察性研究。检索时间为建库至2024年9月。采用Stata17.0软件进行Meta分析。结果 共纳入14项研究，40 582例患者。UIA患者焦虑及抑郁的总体估计发生率为44.2%[95%CI(25.7%，58.7%)]和34.6%[95%CI(24.7%，44.5%)]。亚组分析显示，女性、未接受干预、疾病认知水平低、随访时间短的患者焦虑、抑郁水平更高（均P＜0.05）；而汉密顿焦虑量表和汉密顿抑郁量表的评估结果更接近总体估计发生率。敏感性分析表明研究结果稳定。结论 UIA患者焦虑和抑郁的发生率均较高，临床护理人员可依据上述危险因素制订干预方案，以防止患者负性心理的产生。

Objective To explore the incidence of anxiety and depression in patients with unruptured intracranial aneurysm (UIA)，and to provide a reference for clinical psychological intervention programs.Methods Computerized searches were conducted in both Chinese and English databases for observational studies on the incidence of anxiety and depression in patients with UIA.The search period was from the inceptions to September 2024.Meta-analysis was performed using Stata 17.0 software.Results A total of 14 studies with 40 582 patients were included.UIA incidence of anxiety and depression in patients with overall estimate of 44.2% [95% CI (25.7%，58.7%)]and 34.6% [95% CI (24.7%，44.5%)].Subgroup analysis showed that women，not receiving intervention，low disease cognition level，and short follow-up time had higher levels of anxiety and depression (all P＜0.05).However，the results of the Hamilton Anxiety Scale and the Hamilton Depression Scale were closer to the overall estimated incidence.Sensitivity analysis shows that the results are stable.Conclusions The incidence of anxiety and depression in UIA patients is high，and clinical nurses can make intervention plans according to the above risk factors，so as to prevent the emergence of negative psychology in patients.

R471

山西省科学技术厅自然科学研究面上项目(20210302123351)