目的 探讨多模态运动在血液肿瘤患者异基因造血干细胞移植围术期应用的安全性、可行性及效果，为优化移植患者管理提供依据。 方法 2023年1-12月便利抽样法选择某三级甲等医院收治的异基因造血干细胞移植患者为研究对象，采用随机数字表法将其分为对照组（n=40）和观察组（n=40），对照组采用常规护理模式，观察组在对照组基础上进行多模态运动，比较两组患者的疲乏、睡眠状况及6 min步行距离。 结果两组患者疲乏状况在时间（F_时间=199.977）、组别（F_分组=26.302）及交互效应（F_交互=52.391）上的差异均有统计学意义（均P＜0.001）；住院期间，观察组睡眠状况得分低于对照组（t=2.270），6 min步行距离优于对照组（t=-4.253），差异均有统计学意义（均P＜0.05）。 结论 多模态运动能显著改善血液肿瘤患者异基因造血干细胞移植围术期的疲乏及睡眠状况，提高运动耐力。

Objective To explore the safety，feasibility and effect of multi-types exercises in the perioperative period of allogeneic hematopoietic stem cell transplantation (Allo-HSCT) in patients with hematological malignancies，and to provide a basis for optimizing the nursing care for transplant patients.Methods From January to December 2023，patients who underwent Allo-HSCT in a tertiary A hospital were selected by the convenience sampling method and were randomly divided into a control group (n=40) and an observation group (n=40) using a random number table.The control group received conventional nursing care，while the observation group received multi-types exercises on the basis of the control group.The fatigue，sleep status and 6-minute walking distance of the two groups were compared.Results There were statistically significant differences in fatigue status between the two groups of patients in terms of time（F=199.977），group（F=26.302），and interaction effect（F=52.391,all P＜0.001）.During hospitalization，the sleep status score of the observation group was lower than that of the control group（t=2.270），but the 6-minute walking distance was better than that of the control group （t=-4.253，all P＜0.05）.Conclusions Multi-types exercises can significantly improve fatigue and sleep conditions in patients with hematological malignancies during the perioperative period of Allo-HSCT and enhance exercise endurance.

R473.55；R823

上海市2022年度“科技创新行动计划”医学创新研究专项项目（22Y11911300）