目的 构建宫颈癌同步放化疗患者症状网络并分析网络中心性指标，挖掘症状干预的靶点。方法 便利抽样法选取成都市某三级甲等肿瘤专科医院的宫颈癌同步放化疗患者为研究对象，采用中文版记忆症状评估量表进行调查，通过探索性因子分析提取症状群，使用正则化偏相关网络分析来构建症状网络，并分析中心性指标。结果 宫颈癌患者同步放化疗期间最常见的症状是恶心(62.9%)。提取出3个症状群：情绪症状群、胃肠道症状群以及神经系统相关症状群。网络分析显示，症状间连接密度为0.59。恶心具有最高的强度中心性(r_S=1.56)和预期影响(r_EI=1.56)，手脚麻木刺痛是最重要的桥梁症状(r_bs=0.61)。网络结构稳定性和准确性良好。结论 本研究通过探索性因子提取出宫颈癌同步放化疗期间的三大症状群，通过网络分析揭示了症状网络的关节节点和桥梁症状，不仅深化了对宫颈癌放化疗期间症状复杂性的理解，也为临床实践的精准干预和预防策略提供了新视角和依据。

Objective To construct a symptom network, and to analyze network centrality indices, thereby identifying targets for symptom intervention.Methods Convenience sampling was used to select patients with cervical cancer undergoing concurrent chemoradiotherapy from a tertiary A oncology hospital in Chengdu. The Chinese version of the memorial symptom assessment scale (MSAS-Ch) was used for investigation. Exploratory factor analysis was employed to extract symptom clusters, and regularized partial correlation network analysis was used to construct the symptom network and analyze centrality indices.Results The most common symptom during concurrent chemoradiotherapy was nausea (62.9%). 3 symptom clusters were extracted: an emotional symptom cluster, a gastrointestinal symptom cluster, and a nervous system-related symptom cluster. Network analysis showed that the connection density between symptoms was 0.59. Nausea had the highest strength centrality (r_S=1.56) and expected influence (r_EI=1.56), while numbness and tingling in hands and feet was the most important bridge symptom (r_bs=0.61). The network structure demonstrated good stability and accuracy. Conclusions This study extracted 3 major symptom clusters during concurrent chemoradiotherapy for cervical cancer through exploratory factor analysis, and revealed hub nodes and bridge symptoms within the symptom network via network analysis. These findings not only deepen the understanding of symptom complexity during chemoradiotherapy for cervical cancer but also provide new perspectives and evidence for precise intervention and preventive strategies in clinical practice.

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四川省科技计划(2024JDKP0179)；四川省肿瘤医院优秀青年课题(YB2024010)；四川省肿瘤医院护理专项科研课题(HL202410)；四川省肿瘤医院放疗科中西医协同“旗舰”科室项目(YB2025062022)